产品货号：
Z21038
中文名称：
MMP8抗体
英文名称：
Anti-MMP8 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MMP8 Antibody |
| 指标别名 | CLG1;HNC;Matrix metalloproteinase 8;MMP 8;MMP8;Neutrophil collagenase;PMNL CL;PMNL collagenase |
| 克隆性 | Polyclonal |
| 检验物种 | mouse,rat |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | MMP8 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of mouse MMP-8 (120-157aa HTPQLSRAEVKTAIEKAFHVWSVASPLTFTEILQGEAD),different from the related human sequence by eleven amino acids,and from the related rat sequence by nine amino acids. |
| 实际分子量 | 53KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MMP8 (Matrix metalloproteinase 8) is a member of the family of matrix metalloproteinases.It is distinct from the collagenase of skin fibroblasts and synovial cells in substrate specificity and immunologic crossreactivity.MMP8 is mapped to 11q21-q22.MMP8 is an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes,is expressed by leukocytes and chorionic cytotrophoblast cells.The enzyme exhibits 58% homology to human fibroblast collagenase and has the same domain structure.It consists of a 20-residue signal peptide,and an 80-residue propeptide that is lost on autolytic activation by cleavage of an M-L bond.MMP8 was found to possess 57% identity with the deduced protein sequence for fibroblast collagenase with 72% chemical similarity.Matrix metalloproteinases (MMPs) have fundamental roles in tumor progression,but most clinical trials with MMP inhibitors have not shown improvements in individuals with cancer.MMP8 has a paradoxical protective role in cancer and provides a genetic model to evaluate the molecular basis of gender differences in cancer susceptibility. |
| Uniprot ID | O70138 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | matrix metallopeptidase 8 (neutrophil collagenase) |
| 蛋白名全称 | Neutrophil collagenase |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 ELISA 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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